If someone suffers from extended periods of anxiety, sleeplessness, agitation, or forgetfulness, they may be experiencing the first signs of depression. Depression and major depressive disorder may result from a combination of social and technological advancements. If left untreated, depression can have potentially devastating consequences such as an increased risk of heart disease, substance abuse, and other mental disorders. Nearly 20 million Americans suffer from depression every year, including men, women, and children. Treatment leading to recovery is available through medication, psychotherapy, and options like ketamine infusion therapy.